Further Strengthens Global Intellectual Property Portfolio for Tedopi® in Non-Small Cell Lung Cancer until 2035
OSE Immunotherapeutics announced today that it has received notice of allowance from the United States Patent and Trademark Office for a patent application related to Tedopi®, a combination of neoepitopes, protecting its administration schedule for inducing early T-lymphocyte memory response, used in the treatment of non-small cell lung cancer (NSCLC) in HLA-A2 positive patients. This patent will provide a protection until 2035.
Alexis Peyroles, Chief Executive Officer of OSE Immunotherapeutics, said: “This new patent notice of allowance granted in the U.S. further expands the patent protection for Tedopi® and confirms a specific mechanism of action inducing an early T-lymphocyte memory response in HLA-A2 positive patients, which represent 45% of the population. Our neoepitope approach with Tedopi® was validated by positive results from Step-1 of the Atalante 1 Phase 3 study in NSCLC patients after immune checkpoint failure released in 2020, confirming the clinical benefit Tedopi® can provide to patients who need new therapeutic options for this indication. We are very pleased to present the final results of Atalante 1 in an oral presentation at the 2021 European Society for Medical Oncology (ESMO) conference on September 20. In parallel, we continue to develop Tedopi® in NSCLC after failure from Immune Checkpoint Inhibitors (ICI) as well as in other cancer indications, in combination with ICIs or with chemotherapy. Such combinations will further reinforce the therapeutic value of Tedopi® in late stage cancer indications.”
The Atalante 1 clinical trial aims at evaluating the benefit of Tedopi® in HLA-A2 positive NSCLC patients an invasive stage IIIB or metastatic stage IV, as 2 nd or 3rd line treatment following checkpoint inhibitor failure. The Tedopi® treatment is compared to docetaxel or pemetrexed chemotherapy (CT) treatments, with overall survival as the primary endpoint.